Latios and Latias are siblings.
The protagonists are young adults, instead of pre-teens.
Black and White are two alternate realities.
Team Plasma has attacked trainers and liberated their pokémon.
Giovanni bribed or otherwise got his position as gym leader illicitly.
Orre became a desert wasteland due to a laboratory accident.
"Cinnebar Mansion" was a lab where they did all sorts of horrifying experiments on pokèmon and kidnapped low-class Cinnebar Islanders (bums, drunkards, etc.)
The bags use pokèball technology, allowing storage of massive...
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