I wouldn't mind if they remade Kanto, if they had a different storyline. If they showed the region ten years after blue and red, then it could actually have several cool possibilities.
But sadly, we would probably just get red/green 3.0.
YES YES YES
But I want a MAJOR sequel, where everything takes place after black and white
Everything has changed: all the buildings, all the people, all the cities (except for Lavender town) basically everything, and in somewhere in the plot they should be an epic Mew/Mewtwo battle, where the Kanto birds with the help of all Pokémon would stop them from destroying the world.
THAT WOULD BE AN EPIC DREAM COME TRUE
I completely agree with this, and this person took the words pretty much from my keyboard.
Kanto really has been quite outdone, and to be honest, like the above poster has stated, it really has been on every generation so far. Not even Johto would suffice, any; the only region that would be remotely plausible to see again in the near future would be Hoenn, as Sinnoh is too recent to ever be re-made.