Splicing together existing footage can really only go so far, and would require a lot of effort to find all the words. May appeared in four seasons, plus four movies and a guest appearance during the Wallace Cup arc (nearly two hundred episodes, not counting the Japan exclusive clip show episodes), that's a lot of material to scour.Why do they often tend to either recast, retire, or even kill off characters in Western-produced movies or TV shows if the actor portraying them were to either leave the show or perhaps even die in real life? If May was a Simpsons character, then would she be more like characters like Troy McClure and Lionel Hutz, Maude Flanders, Mrs. Crabapple, or characters like Martin Prince? (Here's a hint: what do these characters all have in common?)
On the other hand, do you think they could potentially "voice" May using several altered recycled audio clips?