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There no fear that Misty gonna chose someone else, That's why it doesn't seem interesting
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Yep, Misty is loyal to Ash even Ash isn't aware of her true feelings. That's at the same time sad and frustrating, but also cute and addictive.
IMO Misty is the best heroine choice for Ash. May is pretty and all, but she's more like a sister to him. And everyone can see the spark between May and Drew.. Dawn is a great person too, but I think it's just a pure friendship what they have there.
I say nothing about Iris, because I don't really know her yet. She doesn't seem like a girl who could care for Ash that way, and neither does Ash towards her.